Baseline Selenium and Prostate Cancer Risk: Comments and Open Questions
نویسندگان
چکیده
منابع مشابه
Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk.
BACKGROUND The Selenium and Vitamin E Cancer Prevention Trial found no effect of selenium supplementation on prostate cancer (PCa) risk but a 17% increased risk from vitamin E supplementation. This case-cohort study investigates effects of selenium and vitamin E supplementation conditional upon baseline selenium status. METHODS There were 1739 total and 489 high-grade (Gleason 7-10) PCa cases...
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Specific interest in selenium as a preventive agent for prostate cancer has arisen recently following the publication of a small number of epidemiologic studies, including a large randomized trial and a case-control study nested in a prospective cohort, suggesting a protective effect of selenium intake on prostate cancer incidence. Recent promising findings for constituents of diet and suppleme...
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Introduction: The purpose of this study is to investigate the relationship of serum selenium levels and the risk of developing prostate cancer. It has been documented that antioxidants reduce the incidence of cancer by eradicating free radicals that damage DNA, thus increasing the risk of cancer. Selenium is a component of the antioxidant enzyme glutathione peroxidase, whose role in cancer prev...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2014
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/dju005